Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens
Articolo
Data di Pubblicazione:
2007
Citazione:
Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens / R. Rhome, T. Mcquiston, T. Kechichian, A. Bielawska, M. Hennig, M. Drago, G. Morace, C. Luberto, M. Del Poeta. - In: EUKARYOTIC CELL. - ISSN 1535-9778. - 6:10(2007 Oct), pp. 1715-1726.
Abstract:
This review summarizes the current understanding of the
role of sphingolipid biosynthesis in the pathobiology of cryptococcosis,
focusing on the production and functions of the
antigenic glycosphingolipid (GSL) glucosylceramide (GlcCer)
and its role in the host-pathogen interaction. In addition, the
presence of GlcCer and structurally similar molecules present
in other pathogens will be discussed and highlighted for their
importance as potential therapeutic targets.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Rhome, T. Mcquiston, T. Kechichian, A. Bielawska, M. Hennig, M. Drago, G. Morace, C. Luberto, M. Del Poeta
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