Data di Pubblicazione:
2007
Citazione:
Statins: multiple mechanisms of action in the ischemic brain [Recensione] / M. Cimino, P. Gelosa, A. Gianella, E. Nobili, E. Tremoli, L. Sironi. - In: NEUROSCIENTIST. - ISSN 1073-8584. - 13:3(2007), pp. 208-213.
Abstract:
Although substantial epidemiological studies have failed to find a correlation between cholesterol levels and stroke, clinical trials have shown that HMG-CoA reductase inhibitors (or statins, the most potent hypocholesterolemic drugs available) greatly reduce the incidence of stroke. These clinical observations have opened the way to a number of studies of the non–cholesterol-dependent (or pleiotropic) effects in animal models of stroke, indicating that the neuroprotection is attributable to multiple activities. One of the main protective mechanisms elicited by statin administration is the increase in nitric oxide bioavailability that regulates cerebral perfusion and improves endothelial function, but others include antioxidant properties, the inhibition of inflammatory responses, immunomodulatory actions, the regulation of progenitor cells, and the stabilization of atherosclerotic plaques. Many of these effects are due to the inhibited synthesis of isoprenoid intermediates, which serve as lipid attachments for a variety of intracellular signaling molecules. This article describes the mechanisms involved in the neuroprotective effects of statins.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animal models; Cerebral ischemia; Nitric oxide; Statin
Elenco autori:
M. Cimino, P. Gelosa, A. Gianella, E. Nobili, E. Tremoli, L. Sironi
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