1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems
Articolo
Data di Pubblicazione:
2007
Citazione:
1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems / M. L. Gelmi, F. Caputo, F. Clerici, S. Pellegrino, G. Giannaccini, L. Betti, L. Fabbrini, L. Schmid, L. Palego, A. Lucacchini. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 15:24(2007), pp. 7581-7589. [10.1016/j.bmc.2007.09.004]
Abstract:
Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Aminocyclopentane-1,2,4-tricarboxylic acids; Chemical resolution; Glutamatergic receptors; Serotoninergic receptors
Elenco autori:
M.L. Gelmi, F. Caputo, F. Clerici, S. Pellegrino, G. Giannaccini, L. Betti, L. Fabbrini, L. Schmid, L. Palego, A. Lucacchini
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