Data di Pubblicazione:
2008
Citazione:
Poly(4-acryloylmorpholine) oligomers carrying a β-cyclodextrin residue at one terminus / M. Bencini, E. Ranucci, P. Ferruti, A. Manfredi, F. Trotta, R. Cavalli. - In: JOURNAL OF POLYMER SCIENCE. PART A, POLYMER CHEMISTRY. - ISSN 0887-624X. - 46:5(2008), pp. 1607-1617.
Abstract:
A straightforward synthesis of amphiphilic b-cyclodextrin-poly(4-acryloylmorpholine)
(b-CD-PACM) polymers of controlled molecular weight, consisting of the
radical polymerization of 4-acryloylmorpholine in the presence of 6-deoxy-6-mercaptob-
cyclodextrin (b-CD-SH) as chain-transfer agent, has been established. These derivatives
carry a single b-cyclodextrin (b-CD) moiety at one terminus and their average
molecular weight is in the order of 104. Thus, their b-CD content is 10% by weight.
No evidence of un-functionalized PACM was found in the final products. The chaintransfer
constant (CT) of b-CD-SH was found to be 1.30 by independently determining
the reaction constants of both chain-transfer and propagation reactions. This ensures
that the molecular weight, hence the b-CD content of the polymers, does not significantly
vary with conversion. These b-CD-PACM polymers are highly soluble in water
as well as in several organic solvents such as chloroform and lower alcohols. They
proved capable of solubilizing in water poorly soluble drugs such as 9-[(2-hydroxyethoxy)
methyl]guanine (Acyclovir) and of gradually releasing them in aqueous systems.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
β-cyclodextrin-poly(4-acryloylmorpholine); Bioactive and biocompatible polymers; Biological applications of polymers; Drug complexation; Drug delivery systems; Drug solubilization; Functionalization of polymers; Hydrophilic polymers
Elenco autori:
M. Bencini, E. Ranucci, P. Ferruti, A. Manfredi, F. Trotta, R. Cavalli
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