Data di Pubblicazione:
2017
Citazione:
Factors affecting outcome of tuberculosis in children in Italy: An ecological study / E. Nicastro, R. Scotto, D. Cerullo, M.C. Fedele, E. Bruzzese, V. Giacomet, M.I. Spagnuolo, A. Guarino, A. Lo Vecchio (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: Advances in Microbiology, Infectious Diseases and Public Health / [a cura di] G. Donelli. - [s.l] : Springer, 2017. - ISBN 9783319607641. - pp. 71-79 [10.1007/5584_2016_94]
Abstract:
INTRODUCTION: Tuberculosis is a major problem in children depending on their families for management and a re-emerging disease in low incidence countries, where foreign-born cases account for a large proportion of cases. METHODS: We investigated socioeconomic features of families and their impact on management and outcome of children with tuberculosis disease seen at a tertiary care centre for paediatric infectious diseases in Italy. RESULTS: Forty-nine Italian and 30 foreign-origin children were included. Children from foreign families had more complicated diseases (20 % vs 0 %; P = 0.002), harbored more drug resistant strains (20 % vs 2 %; P = 0.011), showed longer hospital stay (12 ± 13.1 vs 5.1 ± 6.5 days; P = 0.012) and higher proportion of missed medical visits (15.7 ± 16 vs 8.6 ± 9.6; P ≤ 0.042) than those from Italian families. Harboring drug resistant strains was an independent risk factor for complicated disease course (OR: 72.98; 95 %CI: 1.54–3468.58; P = 0.029), and this risk is higher in children from Eastern Europe (OR: 10.16; 95 %CI: 1.7–61.9; P = 0.012). CONCLUSIONS: Children from immigrant families showed an increased risk of complicated course of tuberculosis due to a higher rate of resistant strains and raise problems in clinical management. Specific protocols are needed to support these populations ensuring easy access to health services and monitoring.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
Tuberculosis; Children; Foreign; Multiresistant
Elenco autori:
E. Nicastro, R. Scotto, D. Cerullo, M.C. Fedele, E. Bruzzese, V. Giacomet, M.I. Spagnuolo, A. Guarino, A. Lo Vecchio
Link alla scheda completa:
Titolo del libro:
Advances in Microbiology, Infectious Diseases and Public Health