ECMM survey of risk factors and practice in the management of invasive yeast infections in European surgical Intensive Care units
Abstract
Data di Pubblicazione:
2007
Citazione:
ECMM survey of risk factors and practice in the management of invasive yeast infections in European surgical Intensive Care units / N.G. Longley, R. Barnes, L. Klingspor, C. Kibbler, J. Meis, M. Ruhnke, A. Tortorano, A. Velegraki, J. Peman, E. Nagy, B. Willinger, A. Kaczur. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - 19:suppl. 3(2007), pp. 90-91. ((Intervento presentato al 3. convegno Trends in medical mycology tenutosi a Torino nel 2007.
Abstract:
We report two cases of central nervous system infection due to methicillin-resistant Staphylococcus epidermidis treated with linezolid. The first case was a 72-year old woman with ventriculitis in the presence of intraventricular catheter: therapeutic effectiveness was documented clinically and microbiologically; serum and cerebrospinal fluid levels were measured after the first and fourth doses: trough linezolid concentrations in cerebrospinal fluid were 1.44 and 2.9 mg/L respectively, higher than the minimum inhibitory concentration (MIC). The second case was a 27-year old man with post-traumatic cerebral abscess; during 5 days linezolid was not found in his cerebrospinal fluid despite very high serum level peak, and the drug was not detectable in cerebral tissue surgically removed after 14 days of therapy. Linezolid may not reach therapeutic concentrations in cerebrospinal fluid, and, when possible, we suggest that drug levels be monitored.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cerebrospinal fluid; Gram positive infection; Linezolid; Therapeutic drug monitoring
Elenco autori:
N.G. Longley, R. Barnes, L. Klingspor, C. Kibbler, J. Meis, M. Ruhnke, A. Tortorano, A. Velegraki, J. Peman, E. Nagy, B. Willinger, A. Kaczur
Link alla scheda completa: