Data di Pubblicazione:
2007
Citazione:
Nitric oxide: emerging concepts about its use in cell-based therapies / Silvia Brunelli, Patrizia Rovere-Querini, Clara Sciorati, A.A. Manfredi, Emilio Clementi. - In: EXPERT OPINION ON INVESTIGATIONAL DRUGS. - ISSN 1354-3784. - 16:1(2007 Jan), pp. 33-43.
Abstract:
Regenerative medicine is an emerging clinical discipline in which cell-based therapies are used to restore the functions of damaged or defective tissues and organs. Along with the well-established use of cells derived from bone marrow or pancreatic islets, novel approaches of cell therapy have recently emerged that appear particularly promising; that is, those using cell-based vaccines and stem cells. This review focuses on the recent developments of these experimental therapeutic approaches and their drawbacks, with specific focus on dendritic cell vaccines in tumours and mesoangioblasts in muscular dystrophies. The authors discuss how the unique properties of a gaseous messenger, NO, may be exploited to overcome some of the drawbacks of these cell-based approaches in combined therapies based on NO-releasing drugs and cell delivery.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cell-based vaccines; cGMP; Dendritic cells; Lymphocytes; Mesoangioblasts; Muscular dystrophy; NO-releasing drugs; Sphingolipids; Stem cells
Elenco autori:
Silvia Brunelli, Patrizia Rovere-Querini, Clara Sciorati, A.A. Manfredi, Emilio Clementi
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