The Impact of Ramadan Fasting on the Reduction of PASI Score, in Moderate-To-Severe Psoriatic Patients: A Real-Life Multicenter Study
Articolo
Data di Pubblicazione:
2019
Citazione:
The Impact of Ramadan Fasting on the Reduction of PASI Score, in Moderate-To-Severe Psoriatic Patients: A Real-Life Multicenter Study / G. Damiani, A. Watad, C. Bridgewood, P.D.M. Pigatto, A. Pacifico, P. Malagoli, N.L. Bragazzi, M. Adawi, G. Damiani. - In: NUTRIENTS. - ISSN 2072-6643. - 11:2(2019 Feb). [10.3390/nu11020277]
Abstract:
Fasting during the month of Ramadan consists of alternate abstinence and re-feeding periods (circadian or intermittent fasting). Nothing is currently known on the impact of this kind of fasting on psoriasis. A sample of 108 moderate-to-severe plaque psoriasis patients (aged 42.84 ± 13.61 years, 62 males, 46 females) volunteered to take part in the study. A significant change in the "Psoriasis Area and Severity Index" (PASI) score before and after the Ramadan fasting (mean difference = -0.89 ± 1.21, p < 0.0001) was found. At the multivariate regression, the use of apremilast (p = 0.0009), cyclosporine (p = 0.0003), phototherapy (p = 0.0015), interleukin-17 or IL-17 blockers (p < 0.0001), and tumor necrosis factor or TNF blockers (p = 0.0107) predicted the PASI score before the Ramadan fasting. Disease duration (p = 0.0078), use of apremilast (p = 0.0005), and of mammalian target of rapamycin or mTOR inhibitors (p = 0.0034) resulted in independent predictors of the change in the PASI score before and after the Ramadan fasting. The consumption of cyclosporine (p < 0.0001), phototherapy (p = 0.0015), IL-17 blockers (p < 0.0001), mTOR inhibitors (p = 0.0081), and TNF blockers (p = 0.0017) predicted the PASI score after the Ramadan fasting. These findings reflect the influence of dieting strategy, the biological clock, and circadian rhythm on the treatment of plaque psoriasis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
biological clock; circadian rhythm; moderate-to-severe psoriatic patients; PASI score; plaque psoriasis; Ramadan intermittent fasting; systemic treatment; Food Science; Nutrition and Dietetics
Elenco autori:
G. Damiani, A. Watad, C. Bridgewood, P.D.M. Pigatto, A. Pacifico, P. Malagoli, N.L. Bragazzi, M. Adawi, G. Damiani
Link alla scheda completa: