Data di Pubblicazione:
2011
Citazione:
KSRP, many functions for a single protein / P. Briata, C. Chen, M. Giovarelli, M. Pasero, M. Trabucchi, A. Ramos, R. Gherzi. - In: FRONTIERS IN BIOSCIENCE. - ISSN 1093-9946. - 16:5(2011), pp. 1787-1796. [10.2741/3821]
Abstract:
KSRP is a single-strand nucleic acids binding protein that affects RNA fate at multiple levels. KSRP modular structure and its complex pattern of posttranslational modifications underpin the interaction with a wide spectrum of RNA target sequences, as well as with other RNA-binding proteins and molecular adaptors. These interactions are important to the regulation of different steps of mRNA metabolism and, in turn, modulate several aspects of cellular proliferation and differentiation. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
mRNA decay; KH-domain; microRNA; AU-rich elements; Review
Elenco autori:
P. Briata, C. Chen, M. Giovarelli, M. Pasero, M. Trabucchi, A. Ramos, R. Gherzi
Link alla scheda completa: