Data di Pubblicazione:
2007
Citazione:
Practical syntheses of pyridinolines, important amino acidic biomarkers of collagen health / P. Allevi, R. Cribiù, E. Giannini, M. Anastasia. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 72:9(2007), pp. 3478-3483.
Abstract:
The paper reports some successful results on the first fully stereoselective total synthesis of the collagen cross-link pyridinolines. All stereogenic centers are stereoselectively introduced using Williams glycine template methodology, and oxazinones are used as a source of chirality and as easily removable protecting groups of the amino acidic functionalities during the assembly of the pyridinoline nucleus.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
pyridinoline ; collagen cross-link ; Williams methodology ; oxazinones
Elenco autori:
P. Allevi, R. Cribiù, E. Giannini, M. Anastasia
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