Platelet concentrates as an adjunctive therapy for medication-related osteonecrosis of the Jaw : a systematic review and meta-analysis
Articolo
Data di Pubblicazione:
2018
Citazione:
Platelet concentrates as an adjunctive therapy for medication-related osteonecrosis of the Jaw : a systematic review and meta-analysis / M. Del Fabbro, S. Taschieri, F. Goker. - In: INTERNATIONAL JOURNAL OF GROWTH FACTORS AND STEM CELLS IN DENTISTRY. - ISSN 2589-7349. - 1:2(2018), pp. 48-57. [10.4103/GFSC.GFSC_19_18]
Abstract:
Medication‑related osteonecrosis of the jaw (MRONJ) is a drug‑related adverse event consisting of progressive bone destruction in the maxillofacial
region of patients under current or previous treatment with antiresorptive or antiangiogenic medications. Autologous platelet concentrates (APC)
demonstrated to enhance bone and soft‑tissue healing in many oral surgery procedures. This systematic review aimed to evaluate APC effect for
treatment and prevention of MRONJ in patients under antiresorptive therapy. An electronic search was performed on MEDLINE, Scopus, Web
of Science, and Cochrane databases using specific search terms, combined with AND, OR. Both prospective and retrospective studies with at
least three patients and 3 months’ follow‑up were included, and they underwent data extraction and risk of bias assessment. When possible, a
meta‑analysis was undertaken. Eighteen studies reporting on 946 patients were included in this study. Postsurgery follow‑up ranged from 3 to
94 months. The adjunct of APC in MRONJ treatment significantly reduced osteonecrosis recurrence with respect to control (P = 0.001). APC
was also beneficial for MRONJ prevention, being associated with a lower MRONJ incidence after tooth extraction (P = 0.03). Heterogeneity was
found regarding medication type, clinical indication, triggering factors, study design, follow‑up duration, type of APC, and outcomes adopted to
evaluate treatment success. Although the results of this review must be cautiously interpreted, due to the low‑evidence level and limited sample
size of the studies included, they are suggestive for possible benefits of APC when associated with surgical procedures for treatment of MRONJ.
To confirm such indication, further prospective comparative studies with large sample size are urgently needed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antiangiogenic agents; antiresorptive agents; bisphosphonates; medication‑related osteonecrosis of the jaw; MRONJ; oral surgery; platelet concentrates; tooth extraction
Elenco autori:
M. Del Fabbro, S. Taschieri, F. Goker
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