Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters
Articolo
Data di Pubblicazione:
2007
Citazione:
Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters / P. Minghetti, S. Sosa, F. Cilurzo, A. Casiraghi, E. Alberti, A. Tubaro, R. Della Loggia, L. Montanari. - In: PLANTA MEDICA. - ISSN 0032-0943. - 73:15(2007), pp. 1525-1530. [10.1055/s-2007-993741]
Abstract:
In this study the skin permeation and the topical anti-inflammatory properties of ginger extracts were investigated. A commercial ginger dry extract (DE) and a gingerols-enriched dry extract (EDE) were evaluated for their in vivo topical anti-inflammatory activity by inhibition of Croton oil-induced ear oedema in mice.
Furthermore, the feasibility of an anti-inflammatory plaster containing DE or EDE was evaluated. Since the in vivo activity was
evaluated in mice, the ex vivo skin permeation study was performed by using mouse skin or human epidermis. The DE from
the acetonic solution exerted a dose-dependent topical anti-inflammatory activity (ID50 = 142μg/cm2), not far from that of the
potent reference substance indomethacin (ID50 = 93μg/cm2). Similarly, the EDE induced a dose-dependent oedema reduction
though its potency (ID50 = 181μg/cm2) was slightly lower than that of DE. Increase of the 6-gingerol concentration in the extract did not improve the anti-inflammatory activity. The medicated plasters, containing 1 mg/cm2 of the commercial DE or EDE, had
good technological characteristics and exerted a significant antiphlogistic effect, too. By using the plaster containing EDE, the 6-gingerol amount that permeated through human epidermis was 6.9 μg/cm2 while the amount that passed through mouse skin was 22.1 μg/cm2. Nevertheless, the amounts of 6-gingerol permeated through human epidermis and mouse skin in the early period (8h) were comparable (p > 0.3). This preliminary result
suggests that the anti-inflammatory effect observed in mice could also be exerted in humans
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adhesive plaster; Croton oil-induced ear oedema; ex vivo skin permeation study; Gingerols; Topical anti-inflammatory activity; Zingiber officinale; Zingiberaceae
Elenco autori:
P. Minghetti, S. Sosa, F. Cilurzo, A. Casiraghi, E. Alberti, A. Tubaro, R. Della Loggia, L. Montanari
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