The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells
Articolo
Data di Pubblicazione:
2018
Citazione:
The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells / J. Rainer, V. Meraviglia, H. Blankenburg, C. Piubelli, P.P. Pramstaller, A. Paolin, E. Cogliati, G. Pompilio, E. Sommariva, F.S. Domingues, A. Rossini. - In: BMC GENOMICS. - ISSN 1471-2164. - 19:1(2018 Jun 25).
Abstract:
Arrhythmogenic cardiomyopathy (ACM) is a genetic autosomal disease characterized by abnormal cell-cell adhesion, cardiomyocyte death, progressive fibro-adipose replacement of the myocardium, arrhythmias and sudden death. Several different cell types contribute to the pathogenesis of ACM, including, as recently described, cardiac stromal cells (CStCs). In the present study, we aim to identify ACM-specific expression profiles of human CStCs derived from endomyocardial biopsies of ACM patients and healthy individuals employing TaqMan Low Density Arrays for miRNA expression profiling, and high throughput sequencing for gene expression quantification.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Arrhythmogenic cardiomyopathy; Cardiac stromal cells; Gene expression; Genomics; Transcriptome profiling; microRNA expression; Arrhythmias, Cardiac; Cardiomyopathies; Gene Expression Profiling; Genomics; Humans; MicroRNAs; Transcriptome
Elenco autori:
J. Rainer, V. Meraviglia, H. Blankenburg, C. Piubelli, P.P. Pramstaller, A. Paolin, E. Cogliati, G. Pompilio, E. Sommariva, F.S. Domingues, A. Rossini
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