Harmonization initiatives in the generation, reporting and application of biological variation data
Articolo
Data di Pubblicazione:
2018
Citazione:
Harmonization initiatives in the generation, reporting and application of biological variation data / A. Aarsand, T. Røraas, W. Bartlett, A. Coşkun, A. Carobene, P. Fernandez-Calle, N. Jonker, J. Díaz-Garzón, F. Braga, S. Sandberg. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1434-6621. - 56:10(2018 Sep 25), pp. 1629-1636. [10.1515/cclm-2018-0058]
Abstract:
Biological variation (BV) data have many applications in laboratory medicine. However, concern has been raised that some LW estimates in use today may be irrelevant or of unacceptable quality. A number of initiatives have been launched by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and other parties to deliver a more harmonized practice in the generation, reporting and application of BV data. Resulting from a necessary focus upon the veracity of historical BV studies, critical appraisal and meta-analysis of published BV studies is possible through application of the Biological Variation Data Critical Appraisal Checklist (BIVAC), published in 2017. The BIVAC compliant large-scale European Biological Variation Study delivers updated high-quality BV data for a wide range of measurands. Other significant developments include the publication of a Medical Subject Heading term for BV and recommendations for common terminology for reporting of BV data. In the near future, global BV estimates derived from meta-analysis of BIVAC appraised publications will be accessible in a Biological Variation Database at the EFLM website. The availability of these high-quality data, which have many applications that impact on the quality and interpretation of clinical laboratory results, will afford improved patient care.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
analytical performance specification; biological variation; evidence-based medicine; meta-analysis; reference change values
Elenco autori:
A. Aarsand, T. Røraas, W. Bartlett, A. Coşkun, A. Carobene, P. Fernandez-Calle, N. Jonker, J. Díaz-Garzón, F. Braga, S. Sandberg
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