Data di Pubblicazione:
2008
Citazione:
Synthesis and biological evaluation of pyrroloiminoquinone derivatives / D. Passarella, F. Belinghieri, M. Scarpellini, G. Pratesi, F. Zunino, O.M. Gia, L. Dalla Via, G. Santoro, B. Danieli. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 2008:5(2008 Mar), pp. 2431-2438.
Abstract:
Synthesis of 10 pyrroloiminoquinone derivatives is presented. The strategy is based around the elaboration of a common
intermediate by reaction with primary amines. All the compounds obtained have been subjected to antiproliferative activity with
three different cell lines (NCI-H460, HeLa, and HL-60). The capacity of 4 selected compounds to affect the enzymatic activity of
the nuclear enzyme DNA topoisomerase II and to form the typical DNA fragmentation which occurs in the apoptotic process is
discussed here.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antiproliferative activity; DNA fragmentation; Pyrroloiminoquinone derivatives; Topoisomerase II
Elenco autori:
D. Passarella, F. Belinghieri, M. Scarpellini, G. Pratesi, F. Zunino, O.M. Gia, L. Dalla Via, G. Santoro, B. Danieli
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