Data di Pubblicazione:
2018
Citazione:
Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development / C. Colombo, O. Pitirollo, L. Lay. - In: MOLECULES. - ISSN 1420-3049. - 23:7(2018 Jul 13). [10.3390/molecules23071712]
Abstract:
During the last decade there has been a growing interest in glycoimmunology, a relatively
new research field dealing with the specific interactions of carbohydrates with the immune system.
Pathogens’ cell surfaces are covered by a thick layer of oligo- and polysaccharides that are crucial
virulence factors, as they mediate receptors binding on host cells for initial adhesion and organism
invasion. Since in most cases these saccharide structures are uniquely exposed on the pathogen
surface, they represent attractive targets for vaccine design. Polysaccharides isolated from cell walls
of microorganisms and chemically conjugated to immunogenic proteins have been used as antigens
for vaccine development for a range of infectious diseases. However, several challenges are associated
with carbohydrate antigens purified from natural sources, such as their difficult characterization and
heterogeneous composition. Consequently, glycoconjugates with chemically well-defined structures,
that are able to confer highly reproducible biological properties and a better safety profile, are at
the forefront of vaccine development. Following on from our previous review on the subject, in the
present account we specifically focus on the most recent advances in the synthesis and preliminary
immunological evaluation of next generation glycoconjugate vaccines designed to target bacterial
and fungal infections that have been reported in the literature since 2011.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
bacterial infections; fungal infections; carbohydrates; glycoconjugates; vaccines
Elenco autori:
C. Colombo, O. Pitirollo, L. Lay
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