Data di Pubblicazione:
2018
Citazione:
Frailty modifications and prognostic impact in older patients admitted in acute care / G. Basile, A. Catalano, G. Mandraffino, G. Maltese, A. Alibrandi, G. Ciancio, D. Brischetto, N. Morabito, A. Lasco, M. Cesari. - In: AGING CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 1594-0667. - (2018 Jun 26). [Epub ahead of print]
Abstract:
Background: Frailty is a predictor of adverse outcomes in older subjects. Aims: The aims of this study are to (1) measure the frailty status and its changes occurring during the hospital stay, (2) determine the relationships among frailty and adverse outcomes. Methods: Frailty was assessed using a 46-item Frailty Index (FI) in 156 patients admitted to an Acute Geriatric Medicine Unit. The FI was calculated within 24 h from the hospital admission (aFI) and at his/her discharge (dFI). Patients were followed up to 12 months after the hospital discharge. Results: A statistically significant difference was reported between the aFI (0.31, IQR 0.19–0.44) and the dFI (0.29, IQR 0.19–0.40; p = 0.04). The aFI was directly associated with the risk of in-hospital death (OR = 5.9; 95% CI 2.0–17.5; p = 0.001), 1 year mortality (OR = 5.5, 95% CI 2.4–12.7, p < 0.001) and re-hospitalization (OR = 6.3, 95% CI 2.2–17.9, p = 0.03). Conclusion: Frailty is a strong predictor of negative endpoints in hospitalized older persons. Discussion: Frailty assessment from routinely collected clinical data may provide important insights about the biological status of the individual and promote the personalization of care.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Elderly; Frailty; Hospitalization; Length of stay; Mortality; Aging; Geriatrics and Gerontology
Elenco autori:
G. Basile, A. Catalano, G. Mandraffino, G. Maltese, A. Alibrandi, G. Ciancio, D. Brischetto, N. Morabito, A. Lasco, M. Cesari
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