Reduction of corticostriatal glutamatergic fibers in basic fibroblast growth factor deficient mice is associated with hyperactivity and enhanced dopaminergic transmission
Articolo
Data di Pubblicazione:
2007
Citazione:
Reduction of corticostriatal glutamatergic fibers in basic fibroblast growth factor deficient mice is associated with hyperactivity and enhanced dopaminergic transmission / P. Fadda, F. Bedogni, A. Fresu, M. Collu, G. Racagni, M.A. Riva. - In: BIOLOGICAL PSYCHIATRY. - ISSN 0006-3223. - 62:3(2007 Aug 01), pp. 235-242.
Abstract:
Background: Basic fibroblast growth factor (FGF2) plays a crucial role during the development of the cerebral cortex. Mice with a knockout of the FGF2 gene have a reduced number of glutamatergic neurons within the deep layers of the cerebral cortex.
Methods: We used molecular and behavioral analyses to investigate possible alterations in corticostriatal function in FGF2-/- mice.
Results: We found that FGF2 deficiency leads to decreased expression of presynaptic markers of integrity for glutamatergic fibers in the striatum, namely the membrane. excitatory amino acid transporter 3 (EAAT3) and the vesicular glutamate transporter 1 (VGLUT1). The reduction of corticostriatal glutamatergic function in FGF2-/- mice is associated with enhanced locomotor activity in a novel environment and increased responsiveness to dopaminergic drugs, such as cocaine or amphetamine. The behavioral alterations of FGF2-/- can be normalized by injection of a low dose of the dopaminergic agonist apomorphine (.1 mg/kg) that reduces dopamine release by acting on presynaptic receptors.
Conclusions: Our data demonsi:rate that FGF2 -/- mice have an increased tone and responsiveness of the dopaminergic system and suggest that these animals might represent a model to study disorders that are characterized by an imbalance between glutamatergic and dopaminergic neurotransmission
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animal model; cocaine; fibroblast growth factor; knockout; prefrontal cortex; schizophrenia
Elenco autori:
P. Fadda, F. Bedogni, A. Fresu, M. Collu, G. Racagni, M.A. Riva
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