Efficacy of oral trazodone slow release following intravenous administration in depressed patients: A naturalistic study
Articolo
Data di Pubblicazione:
2018
Citazione:
Efficacy of oral trazodone slow release following intravenous administration in depressed patients: A naturalistic study / A. Fiorentini, C. Rovera, A. Caldiroli, C. Arici, C.R. Prunas, C. DI PACE, S.M. Paletta, S. MARIA POZZOLI, M. Buoli, A.C. Altamura. - In: RIVISTA DI PSICHIATRIA. - ISSN 2038-2502. - 53:5(2018 Oct), pp. 261-266. [10.1708/3000.30005]
Abstract:
Backgrounds. Up to date, no studies in literature assessed the efficacy of a treatment schedule including i.v. trazodone followed by its oral administration. In light of this lack of evidence, the aim of the present study was to evaluate the efficacy and tolerability of trazodone, administered first i.v. and then orally in a sample of Major Depressive Disorder (MDD) patients. Methods. Thirty four patients underwent i.v. administration of trazodone (75-100 mg in 250 mL of saline) for 1 week. During the second week, oral extended-release formulation (150-300 mg per day) was added to the i.v. administration. Finally, extended-release trazodone was orally administration at doses of
150-300 mg per day. Psychometric scales were performed at baseline (T0), after 2 weeks (T1), 6 weeks (T2), after 3 months (T3), and 6 months (T4). Results. The total sample included 34 subjects (14 males and 20 females). There was a statistically significant decrease in Hamilton Depression Rating Scale total scores from T0 to T1 (t=9.06; df=33), from T1 to T2 (t=4.96; df=29), from T2 to T3 (t=4.08; df=19), and from T3 to T4 (t=2.25; df=19); in Hamilton Anxiety Rating Scale total scores from T0 to T1 (t=8.79; df=33) and from T1 to T2 (t=5.61; df=29); in Montgomery-
Asberg Depression Rating Scale total scores from T0 to T1 (t=9.30; df=33), from T1 to T2 (t=5.69; df=29), and from T2 to T3 (t=3.16; df=19). Conclusions. This finding confirms previous results on depression with concomitant anxiety symptoms: focusing on trazodone prolonged-release formulation, available data documented its efficacy in MDD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
major depressive disorder, antidepressant, trazodone, maintenance treatment
Elenco autori:
A. Fiorentini, C. Rovera, A. Caldiroli, C. Arici, C.R. Prunas, C. DI PACE, S.M. Paletta, S. MARIA POZZOLI, M. Buoli, A.C. Altamura
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