Improving C=N Bond Reductions with (Cyclopentadienone)iron Complexes: Scope and Limitations
Articolo
Data di Pubblicazione:
2019
Citazione:
Improving C=N Bond Reductions with (Cyclopentadienone)iron Complexes: Scope and Limitations / M. Cettolin, X. Bai, D. Lübken, M. Gatti, S. Vailati Facchini, U. Piarulli, L. Pignataro, C. Gennari. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2019:4(2019 Jan 31), pp. 647-654. [10.1002/ejoc.201801348]
Abstract:
Herein, we broaden the application scope of (cyclopentadienone) iron complexes 1 in C=N bond reduction. The catalytic scope of pre-catalyst 1b, which is more active than the “Knölker complex” (1a) and other members of its family, has been expanded to the catalytic transfer hydrogenation (CTH) of a wider range of aldimines and ketimines, either pre-isolated or generated in situ. The kinetics of 1b-promoted CTH of ketimine S1 were assessed, showing a pseudo-first order profile, with TOF = 6.07 h–1 at 50 % conversion. Moreover, the chiral complex 1c and its analog 1d were employed in the enantioselective reduction of ketimines and reductive amination of ketones, giving fair to good yields and moderate enantioselectivity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Transfer hydrogenation; Iron; Amination; Imines; Asymmetric catalysis
Elenco autori:
M. Cettolin, X. Bai, D. Lübken, M. Gatti, S. Vailati Facchini, U. Piarulli, L. Pignataro, C. Gennari
Link alla scheda completa:
Link al Full Text: