Data di Pubblicazione:
2007
Citazione:
Oscillations and temporal signalling in cells / G. Tiana, S. Krishna, S. Pigolotti, M.H. Jensen, K. Sneppen. - In: PHYSICAL BIOLOGY. - ISSN 1478-3967. - 4:2(2007), pp. R01.R1-R01.R17.
Abstract:
The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration using a framework of simple mathematical models. We focus on three eukaryotic genetic regulatory networks which show 'ultradian' oscillations, with a time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53) and immune response (NF-κB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Genetic networks ; cell kinetics
Elenco autori:
G. Tiana, S. Krishna, S. Pigolotti, M.H. Jensen, K. Sneppen
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