Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury
Articolo
Data di Pubblicazione:
2008
Citazione:
Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury / M.C. Toufektsian, M. de Lorgeril, P. Salen, N. Nagy, M.B. Donati, L. Giordano, H.P. Mock, S. Peterek, A. Matros, K. Petroni, R. Pilu, D. Rotilio, C. Tonelli, J. de Leiris, F. Boucher, C. Martins. - In: JOURNAL OF NUTRITION. - ISSN 0022-3166. - 138:4(2008), pp. 747-752.
Abstract:
Consumption of flavonoid-rich foods and beverages is thought to reduce the risk of cardiovascular diseases. Whereas the
biological activities of flavonoids have been characterized in vitro, there are no clear experimental data demonstrating that
chronic dietary intake and intestinal absorption of flavonoids actually protects the heart against ischemia-reperfusion injury.
We tested whether long-term consumption of specific flavonoids (anthocyanins) included in normal food could render the
heart of rats more resistant to myocardial infarction. Maize kernels that differed specifically in their accumulation of anthocyanins
were used to prepare rodent food in which anthocyanins were either present or absent. Male Wistar rats were fed
the anthocyanin-rich (ACN-rich) or the anthocyanin-free (ACN-free) diet for a period of 8 wk. Anthocyanins were significantly
absorbed and detected in the blood and urine of only rats fed the ACN-rich diet. In Langendorff preparations, the hearts of
rats fed the ACN-rich diet were more resistant to regional ischemia and reperfusion insult. Moreover, on an in vivo model of
coronary occlusion and reperfusion, infarct size was reduced in rats that ate the ACN-rich diet than in those that consumed
the ACN-free diet (P,0.01). Cardioprotection was associated with increased myocardial glutathione levels, suggesting that
dietary anthocyanins might modulate cardiac antioxidant defenses. Our findings suggest important potential health benefits
of foods rich in anthocyanins and emphasize the need to develop anthocyanin-rich functional foods with protective activities
for promoting human health.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M.C. Toufektsian, M. de Lorgeril, P. Salen, N. Nagy, M.B. Donati, L. Giordano, H.P. Mock, S. Peterek, A. Matros, K. Petroni, R. Pilu, D. Rotilio, C. Tonelli, J. de Leiris, F. Boucher, C. Martins
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