Data di Pubblicazione:
2018
Citazione:
Cortical markers of cognitive syndromes in amyotrophic lateral sclerosis / M. Consonni, V.E. Contarino, E. Catricalà, E. Dalla Bella, V. Pensato, C. Gellera, G. Lauria, S.F. Cappa. - In: NEUROIMAGE. CLINICAL. - ISSN 2213-1582. - 19(2018), pp. 675-682. [10.1016/j.nicl.2018.05.020]
Abstract:
Amyotrophic lateral sclerosis (ALS) can be associated with a spectrum of cognitive and behavioural symptoms, but the related patterns of focal cortical atrophy in non-demented ALS patients remain largely unknown. We enrolled 48 non-demented ALS patients and 26 healthy controls for a comprehensive neuropsychological assessment and a magnetic resonance exam. Behavioural and cognitive impairment was defined on the basis of a data-driven multi-domain approach in 21 ALS patients. Averaged cortical thickness of 74 bilateral brain regions was used as a measure of cortical atrophy. Cortical thinning in a fronto-parietal network, suggesting a disease-specific pattern of neurodegeneration, was present in all patients, independent of cognitive and behavioural status. Between-group and correlational analyses revealed that inferior frontal, temporal, cingular and insular thinning are markers for cognitive and behavioural deficits, with language impairment mainly related to left temporal pole and insular involvement. These specific correlates support the concept of a spectrum of deficits, with an overlap between the ALS cognitive phenotypes and the syndromes of frontotemporal dementia.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Amyotrophic lateral sclerosis; Cognitive impairment; Cognitive profiles; Cortical thickness; Temporal lobe; Radiology, Nuclear Medicine and Imaging; Neurology; Neurology (clinical); Cognitive Neuroscience
Elenco autori:
M. Consonni, V.E. Contarino, E. Catricalà, E. Dalla Bella, V. Pensato, C. Gellera, G. Lauria, S.F. Cappa
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