Skin autofluorescence is associated with intima media thickness and complements commonly used cardiovascular risk scores
Abstract
Data di Pubblicazione:
2007
Citazione:
Skin autofluorescence is associated with intima media thickness and complements commonly used cardiovascular risk scores / D.J. Mulder, P.L. Van Haelst, R. Graaff, R.O. Gans, F. Zijlstra, D. Baldassarre, A.J. Smit. - In: ATHEROSCLEROSIS SUPPLEMENTS. - ISSN 1567-5688. - 8:1(2007), pp. 106-106. ((Intervento presentato al 76. convegno Congress of the European Atherosclerosis Society (EAS) tenutosi a Helsinki, Finland nel 2007 [10.1016/S1567-5688(07)71371-5].
Abstract:
Background and Aims: Skin autofluorescence (AF) is a non-invasive
marker for Advanced Glycation Endproducts which are protein bound
compounds derived from glycaemic and oxidative stress. We aimed to
assess whether skin AF is associated with carotid intima media thickness
(IMT) and vascular risk factors (VRFs), and complements cardiovascular
risk scores in identifying subjects with increased IMT.
Methods: This was a cross-sectional local sub study to the “Carotid
Intima Media Thickness and IMT-Progression as Predictors of Vascular
Events in a High Risk European Population (IMPROVE)” study. 186
subjects with ≥3 VRFs without a history of cardiovascular disease (CVD)
were included. Skin AF was measured on the lower arm, using a prototype
of the current AGE-Reader. IMT was measured with a high-resolution
ESAOTE ultrasound system.
Results: Skin AF correlated with IMT (r=0.15; P=0.039), C-reactive
protein (r=0.19; P=0.015), leukocyte count (r=0.27; P<0.001), waist circumference
(r=0.24; P=0.002), BMI (r=0.25; P=0.001), and fasting glucose
(r=0.21; P=0.007), and was higher in smokers (P=0.038), even after
correction for age. Combining FRS or SCORE with skin AF improved the
prediction of IMT (see figure).
Conclusion: Skin AF is age independently associated with carotid IMT,
inflammation, and VRFs, and may add incremental information to global
risk assessment scores in identifying asymptomatic subjects at high risk for
CVD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Arterial structure ; cardiovascular risk factors
Elenco autori:
D.J. Mulder, P.L. Van Haelst, R. Graaff, R.O. Gans, F. Zijlstra, D. Baldassarre, A.J. Smit
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