Data di Pubblicazione:
1985
Citazione:
La flunarizina nel trattamento delle arteriopatie degli arti inferiori / M. Catalano, E. Sacchi, M. Tomasini, E. Coazzoli, A. Parolini, A. Dall'Oglio, A. Libretti. - In: LA RICERCA IN CLINICA E IN LABORATORIO. - ISSN 0390-5748. - 15:suppl. 1(1985), pp. 475-478.
Abstract:
Flunarizine, a long-acting calcium antagonist, was studied in patients with peripheral vascular disease in order to assess its effects on blood viscosity, erythrocyte deformability, platelet activity and some clinical parameters. A randomized double-blind study was performed; all patients were given a standard diet, invited to abstain from smoking and to carry out a regular daily exercise (walking). After a 2-month run-in period the patients were divided into two groups: one was treated with flunarizine 10 mg/day and the other with placebo. The group treated with flunarizine presented marked and significant reduction of erythrocyte filtration time and blood viscosity and an improvement of the treadmill-free interval with a correlation between the parameters considered.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Aged; Blood Viscosity; Calcium Channel Blockers; Cinnarizine; Double-Blind Method; Erythrocyte Deformability; Flunarizine; Humans; Intermittent Claudication; Middle Aged; Piperazines; Platelet Aggregation; Rheology
Elenco autori:
M. Catalano, E. Sacchi, M. Tomasini, E. Coazzoli, A. Parolini, A. Dall'Oglio, A. Libretti
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