Data di Pubblicazione:
2018
Citazione:
Effect of acylation on the antimicrobial activity of temporin B analogues / C. Avitabile, L.D. D'Andrea, E. D'Aversa, R. Milani, R. Gambari, A. Romanelli. - In: CHEMMEDCHEM. - ISSN 1860-7179. - 13:15(2018 Aug 10), pp. 1549-1554. [10.1002/cmdc.201800289]
Abstract:
New peptides derived from the natural antimicrobial temporin B were obtained. The design, the antimicrobial activity as well as the characterization of the secondary structure of peptides in the presence of bacterial cells is here described. We identified TB_KKG6K (KKLLPIVKNLLKSLL) as the most active analogue against Gram-positive and Gram-negative bacteria as compared to natural temporin B (LLPIVGNLLKSLL) and TB_KKG6A (KKLLPIVANLLKSLL). Acylation with hydrophobic moieties led generally to reduced activity, however, acylation at position 6 of TB_KKG6K led to retained submicromolar activity against Staphylococcus epidermidis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
acylation; antimicrobial activity; peptides; secondary structures; substituent effects; antimicrobial; acylatio;; circular dichroism; E. coli ; S. epidermidis
Elenco autori:
C. Avitabile, L.D. D'Andrea, E. D'Aversa, R. Milani, R. Gambari, A. Romanelli
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