Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes
Articolo
Data di Pubblicazione:
2005
Citazione:
Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes / A. Perez Rebolledo, J.D. Ayala, G.M. de Lima, N. Marchini, G. Bombieri, C.L. Zani, E.M. Souza Fagundes, H. Beraldo. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 40:5(2005), pp. 467-472. [10.1016/j.ejmech.2005.01.006]
Abstract:
Structural studies and an investigation of the cytotoxic activity of Sn(IV) complexes with N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph) were carried out. The crystal and molecular structures of [Sn(2Bz4Ph)Cl-3]center dot CH3CH2OH (1) and [Sn(2Bz4Ph)BuCl2]center dot H2O (Bu = butyl group) (2) were determined. Both compounds present octahedral coordination geometry with the 2Bz4Ph anionic ligand behaving as tridentate on the metal ion. A comparative study of the structures of these compounds along with that of [Sn(2Bz4Ph)Bu2Cl] (3) determined before is presented. The cytotoxicity of H2Bz4Ph and its Sn(IV) complexes was investigated against the MCF-7, TK-10 and UACC-62 human tumor cell lines. Among the three complexes, 3 proved to be better as cytotoxic agent than the clinically used drug etoposide. H2Bz4Ph and all complexes were able to induce apoptosis in UACC-62 cells.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
thiosemicarbazones; tin(IV) complexes; crystal structures; cytotoxic activity
Elenco autori:
A. Perez Rebolledo, J.D. Ayala, G.M. de Lima, N. Marchini, G. Bombieri, C.L. Zani, E.M. Souza Fagundes, H. Beraldo
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