Data di Pubblicazione:
2005
Citazione:
Ovarian epithelioid trophoblastic tumor in a cynomolgus monkey / A. M. F. Giusti, A. Terron, S. Belluco, E. Scanziani, M. L. Carcangiu. - In: VETERINARY PATHOLOGY. - ISSN 0300-9858. - 42:2(2005), pp. 223-226.
Abstract:
Epithelioid trophoblastic tumor (ETT) is an unusual type of trophoblastic tumor, with features resembling carcinoma. In this study, we describe a 4-year-old cynomolgus monkey (Macaca fascicularis) showing, at necropsy, a lobulated mass replacing the left ovary and several nodular lesions within the lungs. Histologically, the mass in the ovary and lung metastases were characterized by nests of epithelioid cells, with intermingled, occasional, inultinucleate tumor cells consistent with syncytiotrophoblasts and moderate amount of eosinophilic, hyaline-like material. Immunohistochemically, the tumor cells were diffusely positive for cytokeratins (AE1/AE3) and inhibin-alpha, but only focal immunoreactivity was observed for human chorionic gonadotropin, whereas placental alkaline phosphatase was always negative. On the basis of morphology and immunohistochemical reactivity, tumor cells were identified as intermediate trophoblast.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cynomolgus monkey; epithelioid trophoblastic tumor; ovary
Elenco autori:
A. M. F. Giusti, A. Terron, S. Belluco, E. Scanziani, M. L. Carcangiu
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