Simulating patterns of excitation, repolarization and action potential duration with cardiac bidomain and monodomain models
Articolo
Data di Pubblicazione:
2005
Citazione:
Simulating patterns of excitation, repolarization and action potential duration with cardiac bidomain and monodomain models / P. Colli Franzone, L.F. Pavarino, B. Taccardi. - In: MATHEMATICAL BIOSCIENCES. - ISSN 0025-5564. - 197:1(2005), pp. 35-66.
Abstract:
Parallel numerical simulations of excitation and recovery in three-dimensional myocardial domains are presented. The simulations are based on the anisotropic Bidomain and Monodomain models, including intramural fiber rotation and orthotropic or axisymmetric anisotropy of the intra- and extra-cellular conductivity tensors. The Bidomain model consist of a system of two reaction–diffusion equations, while the Monodomain model consists of one reaction–diffusion equation. Both models are coupled with the phase I Luo–Rudy membrane model describing the ionic currents. Simulations of excitation and repolarization sequences on myocardial slabs of different sizes show how the distribution of the action potential durations (APD) is influenced by both the anisotropic electrical conduction and the fiber rotation. This influence occurs in spite of the homogeneous intrinsic properties of the cell membrane. The APD dispersion patterns are closely correlated to the anisotropic curvature of the excitation wavefront.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Action potential duration; Cardiac Bidomain and Monodomain models; Excitation and repolarization processes; Myocardial anisotropy; Numerical simulations; Reaction-diffusion equations
Elenco autori:
P. Colli Franzone, L.F. Pavarino, B. Taccardi
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