Effects of mechanical feedback on the stability of cardiac scroll waves: A bidomain electro-mechanical simulation study
Articolo
Data di Pubblicazione:
2017
Citazione:
Effects of mechanical feedback on the stability of cardiac scroll waves: A bidomain electro-mechanical simulation study / P. Colli Franzone, L.F. Pavarino, S. Scacchi. - In: CHAOS. - ISSN 1054-1500. - 27:9(2017 Sep). [10.1063/1.4999465]
Abstract:
In this work, we investigate the influence of cardiac tissue deformation on re-entrant wave dynamics. We have developed a 3D strongly coupled electro-mechanical Bidomain model posed on an ideal monoventricular geometry, including fiber direction anisotropy and stretch-activated currents (SACs). The cardiac mechanical deformation influences the bioelectrical activity with two main mechanical feedback: (a) the geometric feedback (GEF) due to the presence of the deformation gradient in the diffusion coefficients and in a convective term depending on the deformation rate and (b) the mechano-electric feedback (MEF) due to SACs. Here, we investigate the relative contribution of these two factors with respect to scroll wave stability. We extend the previous works [Keldermann et al., Am. J. Physiol. Heart Circ. Physiol. 299, H134-H143 (2010) and Hu et al., PLoS One 8(4), e60287 (2013)] that were based on the Monodomain model and a simple non-selective linear SAC, while here we consider the full Bidomain model and both selective and non-selective components of SACs. Our simulation results show that the stability of cardiac scroll waves is influenced by MEF, which in case of low reversal potential of non-selective SACs might be responsible for the onset of ventricular fibrillation; GEF increases the scroll wave meandering but does not determine the scroll wave stability.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
statistical and nonlinear physics; mathematical physics; physics and astronomy (all); applied mathematics
Elenco autori:
P. Colli Franzone, L.F. Pavarino, S. Scacchi
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