Data di Pubblicazione:
2000
Citazione:
Transient global amnesia: a review emphasizing pathogenic aspects / L. Pantoni, M. Lamassa, D. Inzitari. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - 102:5(2000 Nov), pp. 275-283. [10.1034/j.1600-0404.2000.102005275.x]
Abstract:
The transitory memory disturbance known as transient global amnesia (TGA) remains an enigma from a pathogenic point of view. In spite of its typical benign prognosis, TGA is a frightening experience for patients and their relatives. Moreover, a TGA episode usually leads to extensive investigation of patients in search of organic alterations that might be responsible for the event. Finally, TGA generates queries about therapeutic choices. In this review, we critically re-evaluate the evidence in support of and against the three main pathogenic hypotheses (i.e. ischemia, seizure discharge, and migraine), and we conclude that none of these appears completely convincing. Given the good prognosis and the lack of association with organic and instrumental abnormalities, we advance the hypothesis that TGA may be related to psychological disturbances causing transient alteration in brain metabolism and, consequently, amnesia. Our conclusion has relevant consequences in the evaluation of patients with TGA.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
transient global amnesia; pathogenesis; cerebral ischemia; migraine; epilepsy; panic attack; agoraphobia; spreading depression
Elenco autori:
L. Pantoni, M. Lamassa, D. Inzitari
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