Time since menopause does not affect plasma viscosity, plasma thromboxane levels and Doppler findings
Articolo
Data di Pubblicazione:
2005
Citazione:
Time since menopause does not affect plasma viscosity, plasma thromboxane levels and Doppler findings / F. Mancini, N. Persico, G. Regnani, A. Volpe, C. Battaglia, D. de Aloysio. - In: GYNECOLOGICAL ENDOCRINOLOGY. - ISSN 0951-3590. - 20:3(2005 Mar), pp. 170-175.
Abstract:
Objectives. To evaluate whether the use of transdermal hormone replacement therapy (HRT), in women within 5 years of menopause compared with women who were postmenopausal for > 5 years, would significantly influence thromboxane B-2 levels, plasma viscosity and Doppler flow parameters at the level of the uterine, internal carotid, ophthalmic and bladder wall arteries.
Methods. Thirty-five normal-weight (body mass index > 19 and < 25 kg/m(2)) postmenopausal women (age 54.6 &PLUSMN; 3.9 years, mean &PLUSMN; standard deviation) participated in the study and were divided into two groups (Group I: n = 19, time since menopause < 5 years.- and Group II: n = 16, time since menopause > 5 years). Patients were treated with a continuous estradiol transidermal supplementation and 12-day courses of medroxyprogesterone acetate every 2 months. They were studied at baseline and after 6 months (in the estrogen-only phase of the cycle).
Results. Results showed a beneficial effect of hormone substitution after 6 months of therapy. Baseline plasma viscosity was similar in both groups, and decreased significantly after therapy in both Group I (-17.5%) and Group II (-15.6%). Plasma levels of thromboxane B-2 were similar at baseline and diminished equally in Group I and Group II (-85.6% and - 85.2%, respectively) after treatment. Doppler assessment of the pulsatility index at the level of uterine, internal carotid, ophthalmic and bladder wall arteries showed no differences between groups at baseline and revealed a significant reduction of vascular impedance at the end of the treatment in both groups.
Conclusions. Time since menopause does not affect the potential hemodynamic benefits of HRT in normal-weight women.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Body Mass Index; Estrogen Replacement Therapy; Female; Humans; Laser-Doppler Flowmetry; Menopause; Middle Aged; Pulsatile Flow; Thromboxane B2; Time Factors; Blood Viscosity
Elenco autori:
F. Mancini, N. Persico, G. Regnani, A. Volpe, C. Battaglia, D. de Aloysio
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