Cardiovascular risk in normal weight, eumenorrheic, nonhirsute daughters of patients with polycystic ovary syndrome: a pilot study
Articolo
Data di Pubblicazione:
2009
Citazione:
Cardiovascular risk in normal weight, eumenorrheic, nonhirsute daughters of patients with polycystic ovary syndrome: a pilot study / C. Battaglia, F. Mancini, A. Cianciosi, P. Busacchi, N. Persico, R. Paradisi, F. Facchinetti, D. de Aloysio. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 92:1(2009 Jul), pp. 240-249.
Abstract:
Objective: To verify whether healthy daughters with polycystic ovaries (PCO) of patients with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease in comparison with healthy controls.
Design: Prospective observational study.
Setting: University hospital.
Patient(s): Seventeen eumenorrheic daughters with PCO of patients with PCOS (group 1) and 20 healthy volunteers (group 2) with regular ovulatory cycles,
Intervention(S): Fasting blood sampling, ultrasonographic and Doppler analyses, 24-hour ambulatory blood pressure monitoring.
Main Outcome Measure(s): Medical examination; blood measurement of nitrites and nitrates, biochemical and hormonal parameters; utero-ovarian ultrasonographic analysis and color Doppler evaluation of uterine and stromal ovarian arteries; brachial artery flow-mediated vasodilatation; 24-hour ambulatory blood pressure monitoring. An oral glucose tolerance test was performed to analyze glucose, insulin, and C-peptide levels.
Result(S): At Doppler analysis a significantly higher uterine and a lower ovarian artery pulsatitity index was found in group I compared with group 2. The brachial artery diameter, after the reactive hyperemia, showed a greater vasodilatation in controls in comparison with women with PCO. The 24-hour blood pressure monitoring demonstrated that patients with PCO have significant higher 24-hour, daytime, and nighttime diastolic and mean arterial pressure values than controls. The nitrites and nitrates plasma levels were lower in group 1 compared with group 2. The glucose and insulin plasma values were higher in patients with PCO than in controls.
Conclusion(s): Eumenorrheic nonhirsute daughters of patients with PCOS who have PCO appearance on ultrasound have an increased cardiovascular risk.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Blood Flow Velocity; Blood Pressure Monitoring, Ambulatory; Body Weight; Brachial Artery; Cardiovascular Diseases; Female; Humans; Menstruation; Mothers; Ovary; Pilot Projects; Polycystic Ovary Syndrome; Prospective Studies; Reference Values; Risk Factors; Ultrasonography; Uterus; Vasodilation
Elenco autori:
C. Battaglia, F. Mancini, A. Cianciosi, P. Busacchi, N. Persico, R. Paradisi, F. Facchinetti, D. de Aloysio
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