Data di Pubblicazione:
2011
Citazione:
Liver volume in trisomy 21 and euploid fetuses at 11 to 13 weeks / Y. Gielchinsky, M. Zvanca, R. Minekawa, N. Persico, K.H. Nicolaides. - In: PRENATAL DIAGNOSIS. - ISSN 1097-0223. - 31:1(2011 Jan), pp. 28-32. [10.1002/pd.2633]
Abstract:
OBJECTIVES:
To compare liver volume between trisomy 21 and euploid fetuses at 11 to 13 weeks' gestation.
METHODS:
Fetal liver volume was measured by 3D ultrasound in fetuses at low risk of aneuploidies (n = 200) and another group at high risk, including 148 euploid and 37 with trisomy 21. The association of liver volume with fetal nuchal translucency (NT) thickness, tricuspid regurgitation and reversed a-wave in the ductus venosus was investigated.
RESULTS:
In the low-risk group, fetal liver volume increased exponentially with fetal crown-rump length (CRL) from a median of 0.5 cm(3) at CRL of 45 mm to about 2.5 cm(3) at CRL of 84 mm. In 27 (73.0%) of the trisomy 21 fetuses liver volume was above the 95th percentile of the low-risk group, whereas in the euploid fetuses liver volume was not significantly altered (P = 0.521). There were no significant contributions to liver volume from fetal NT (P = 0.508), tricuspid regurgitation (P = 0.958) or reversed a-wave in the ductus venosus (P = 0.872).
CONCLUSION:
In trisomy 21 fetuses at 11 to 13 weeks liver volume is increased.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adult; Crown-Rump Length; Down Syndrome; Female; Fetal Heart; Humans; Liver; Nuchal Translucency Measurement; Pregnancy; Retrospective Studies; Tricuspid Valve Insufficiency; Ultrasonography, Prenatal; Gestational Age
Elenco autori:
Y. Gielchinsky, M. Zvanca, R. Minekawa, N. Persico, K.H. Nicolaides
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