A stereoselective, catalytic strategy for the in-flow synthesis of advanced precursors of Rasagiline and Tamsulosin
Articolo
Data di Pubblicazione:
2017
Citazione:
A stereoselective, catalytic strategy for the in-flow synthesis of advanced precursors of Rasagiline and Tamsulosin / D. Brenna, M. Pirola, L. Raimondi, A.J. Burke, M. Benaglia. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 25:23(2017 Dec 01), pp. 6242-6247. [10.1016/j.bmc.2017.01.023]
Abstract:
The diastereoselective, trichlorosilane-mediate reduction of imines, bearing different and removable chiral auxiliaries, in combination either with achiral bases or catalytic amounts of chiral Lewis bases, was investigated to afford immediate precursors of chiral APIs (Active Pharmaceutical Ingredients). The carbon-nitrogen double bond reduction was successfully performed in batch and in flow mode, in high yields and almost complete stereocontrol. By this metal-free approach, the formal synthesis of rasagiline and tamsulosin was successfully accomplished in micro(meso) flow reactors, under continuous flow conditions. The results of these explorative studies represent a new, important step towards the development of automated processes for the preparation of enantiopure biologically active compounds
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Active pharmaceutical ingredients; Chiral amines; Flow chemistry; Flow reactors; Metal-free catalysis; Reduction; Stereoselective synthesis
Elenco autori:
D. Brenna, M. Pirola, L. Raimondi, A.J. Burke, M. Benaglia
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