Data di Pubblicazione:
2008
Citazione:
On the etiology of incident brain lacunes : longitudinal observations from the LADIS study / A.A. Gouw, W.M. Van Der Flier, L. Pantoni, D. Inzitari, T. Erkinjuntti, L.O. Wahlund, G. Waldemar, R. Schmidt, F. Fazekas, P. Scheltens, F. Barkhof. - In: STROKE. - ISSN 0039-2499. - 39:11(2008 Nov), pp. 3083-3085.
Abstract:
BACKGROUND AND PURPOSE:
We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period.
METHODS:
Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors.
RESULTS:
106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes.
CONCLUSIONS:
Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Lacunes; MRI; White matter hyperintensities; Basal Ganglia; Humans; Leukoaraiosis; Longitudinal Studies; Magnetic Resonance Imaging; Nerve Fibers, Myelinated; Risk Factors; Brain Infarction; Neurology (clinical); Cardiology and Cardiovascular Medicine; Advanced and Specialized Nursing
Elenco autori:
A.A. Gouw, W.M. Van Der Flier, L. Pantoni, D. Inzitari, T. Erkinjuntti, L.O. Wahlund, G. Waldemar, R. Schmidt, F. Fazekas, P. Scheltens, F. Barkhof
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