Daylight methyl-aminolevulinate photodynamic therapy versus ingenol mebutate for the treatment of actinic keratoses : an intraindividual comparative analysis
Articolo
Data di Pubblicazione:
2016
Citazione:
Daylight methyl-aminolevulinate photodynamic therapy versus ingenol mebutate for the treatment of actinic keratoses : an intraindividual comparative analysis / G. Genovese, D. Fai, C. Fai, L. Mavilia, S.R. Mercuri. - In: DERMATOLOGIC THERAPY. - ISSN 1396-0296. - 29:3(2016), pp. 191-196.
Abstract:
Daylight-photodynamic therapy (D-PDT) and ingenol mebutate (IM) are novel therapies directed to actinic keratoses (AK). The purpose of our study was to compare effectiveness, tolerability, cosmetic outcome and patient preference of D-PDT versus IM in the treatment of grade I and II AK. Twenty-seven patients with AK on the face or scalp were enrolled. Each patient received, in a 25 cm2 target area, D-PDT on right side and IM on left side. Overall 323 AK were treated. Both target areas achieved complete response in 40.47% of the cases and average AK clearance rate was similar for D-PDT and IM (p=0.74). In D-PDT areas mean grade II AK clearance rate was lower compared with that of grade I AK (p=0.015). In IM areas grade I and II AK average clearance rates were similar (p=0.28). At week 1 and month 1, mean local skin responses (LSR) score were higher in areas treated with IM. IM areas showed more severe pain and cosmetic sequelae. D-PDT had similar effectiveness to IM, even if IM demonstrated higher grade II AK clearance rate. Tolerability profile was superior for D-PDT in terms of LSR and pain. D-PDT was more cosmetically acceptable. Patients preferred D-PDT to IM in most cases.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
actinic keratosis; daylight photodynamic therapy; field cancerization; ingenol mebutate; methyl-aminolevulinate; Aged; Aged, 80 and over; Aminolevulinic Acid; Dermatologic Agents; Diterpenes; Facial Dermatoses; Female; Humans; Keratosis, Actinic; Male; Middle Aged; Patient Preference; Photochemotherapy; Photosensitizing Agents; Remission Induction; Scalp Dermatoses; Surveys and Questionnaires; Time Factors; Treatment Outcome; Sunlight; 2708
Elenco autori:
G. Genovese, D. Fai, C. Fai, L. Mavilia, S.R. Mercuri
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