Data di Pubblicazione:
2017
Citazione:
Human Polyomaviruses: The Battle of Large and Small Tumor Antigens / C.F. Baez, R. Brandão Varella, S. Villani, S. Delbue. - In: VIROLOGY. - ISSN 1178-122X. - 8:(2017 Dec), pp. 1-12. [10.1177/1178122X17744785]
Abstract:
About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To date, it is well known that all the discovered human PyVs (HPyVs) encode these 2 multifunctional and tumorigenic proteins, expressed at viral replication early stage. The 2 T-Ags are able to transform cells both in vitro and in vivo and seem to play a distinct role in the pathogenesis of some tumors in humans. In addition, they are involved in viral DNA replication, transcription, and virion assembly. This short review focuses on the structural and functional features of the HPyVs' LT-Ag and sT-Ag, with special attention to their transforming properties.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Polyomavirus; large T antigen; neoplasia; small T antigen
Elenco autori:
C.F. Baez, R. Brandão Varella, S. Villani, S. Delbue
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