Data di Pubblicazione:
2017
Citazione:
Has VZV epidemiology changed in Italy? Results of a seroprevalence study / D.D. Antonella, K. Parvanè, G. Marcello, R. Maria Cristina, B. Antonino, B. Giordana, L. Silvia, I. Adele, S. Armando, D.M. Martina, G. Giovanni, G. Cristina, G. Francesca, G. Anna Maria, R. Clelia, M. Francesco, S. Silvana, C. Paolo, P. Andrea, V. Paolo, M. Pierangela, G. Anna, P. Elisabetta, R. Patrizia, C. Manuela, D. Gabriele, T. Maria Rosaria, M. Marcella, B. Francesco, Z. Antonella, A. Emanuele, S. Valentina, C. Manuela, V. Francesco, B. Vincenzo, B. Tatjana, T. Emilia, B. Paolo, B. Patrizia, P. Marta, Z. Carla, C. Elena, D. Savina, S. Binda, L. Pellegrinelli, V. Primache, G. Tolinda, D. Pierlanfranco, S. Ludovica, B. Roberto, S. Laura, C. Patrizia, T. Cecilia, G. Giovanni, B. Chiara, V. Monica, B. Sergio, C. Paolo, P. Marco, F. Paolo, C. Luigi, G. Guido, S. Michela Lucia, P. Anna Rita, R. Paolo, R. Caterina, A. Italo, D.G. Gabriella, P. Basilio, S. Stefania, C. Elvira, B. Danila. - In: HUMAN VACCINES & IMMUNOTHERAPEUTICS. - ISSN 2164-5515. - 13:2(2017), pp. 385-390. [10.1080/21645515.2017.1264828]
Abstract:
The aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a
seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era.
During 2013–2014, sera obtained from blood samples taken for diagnostic purposes or routine investigations
were collected in collaboration with at least one laboratory/center for each region, following the approval of
the Ethics Committee. Data were stratified by sex and age. All samples were processed in a national reference
laboratory by an immunoassay with high sensitivity and specificity. Statutory notifications, national hospital
discharge database and mortality data related to VZV infection were analyzed as well. A total of 3707 sera
were collected and tested. In the studied period both incidence and hospitalization rates decreased and about
5 deaths per year have been registered. The seroprevalence decreased in the first year of life in subjects
passively protected by theirmother, followed by an increase in the following age classes. The overall antibody
prevalence was 84%. The comparison with surveys conducted with the samemethodology in 1996–1997 and
2003–2004 showed significant differences in age groups 1–19 y. The study confirms that in Italy VZV infection
typically occurs in children. The impact of varicella on Italian population is changing. The comparison between
studies performed in different periods shows a significant increase of seropositivity in age class 1 – 4 years,
expression of vaccine interventions already adopted in some regions.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
chickenpox; immunization; seroprevalence; surveillance; varicella-zoster virus; adolescent; adult; age factors; aged; aged, 80 and over; antibodies, viral; chickenpox; child; child, preschool; cross-sectional studies; female; humans; infant; infant, newborn; italy; male; middle aged; seroepidemiologic studies; young adult; immunology and allergy; immunology; pharmacology
Elenco autori:
D.D. Antonella, K. Parvanè, G. Marcello, R. Maria Cristina, B. Antonino, B. Giordana, L. Silvia, I. Adele, S. Armando, D.M. Martina, G. Giovanni, G. Cristina, G. Francesca, G. Anna Maria, R. Clelia, M. Francesco, S. Silvana, C. Paolo, P. Andrea, V. Paolo, M. Pierangela, G. Anna, P. Elisabetta, R. Patrizia, C. Manuela, D. Gabriele, T. Maria Rosaria, M. Marcella, B. Francesco, Z. Antonella, A. Emanuele, S. Valentina, C. Manuela, V. Francesco, B. Vincenzo, B. Tatjana, T. Emilia, B. Paolo, B. Patrizia, P. Marta, Z. Carla, C. Elena, D. Savina, S. Binda, L. Pellegrinelli, V. Primache, G. Tolinda, D. Pierlanfranco, S. Ludovica, B. Roberto, S. Laura, C. Patrizia, T. Cecilia, G. Giovanni, B. Chiara, V. Monica, B. Sergio, C. Paolo, P. Marco, F. Paolo, C. Luigi, G. Guido, S. Michela Lucia, P. Anna Rita, R. Paolo, R. Caterina, A. Italo, D.G. Gabriella, P. Basilio, S. Stefania, C. Elvira, B. Danila
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