Cancer and frailty in older adults : a nested case-control study of the Mexican Health and Aging Study
Articolo
Data di Pubblicazione:
2016
Citazione:
Cancer and frailty in older adults : a nested case-control study of the Mexican Health and Aging Study / M.U. Pérez-Zepeda, E. Cárdenas-Cárdenas, M. Cesari, A.P. Navarrete-Reyes, L.M. Gutiérrez-Robledo. - In: JOURNAL OF CANCER SURVIVORSHIP. - ISSN 1932-2259. - 10:4(2016), pp. 736-742. [10.1007/s11764-016-0519-6]
Abstract:
PURPOSE:
Understanding how the convergence between chronic and complex diseases-such as cancer-and emerging conditions of older adults-such as frailty-takes place would help in halting the path that leads to disability in this age group. The objective of this manuscript is to describe the association between a past medical history of cancer and frailty in Mexican older adults.
METHODS:
This is a nested in cohort case-control study of the Mexican Health and Aging Study. Frailty was categorized by developing a 55-item frailty index that was also used to define cases in two ways: incident frailty (incident >0.25 frailty index score) and worsening frailty (negative residuals from a regression between 2001 and 2012 frailty index scores). Exposition was defined as self-report of cancer between 2001 and 2012. Older adults with a cancer history were further divided into recently diagnosed (<10 years) and remotely diagnosed (>10 years from the initial diagnosis). Odds ratios were estimated by fitting a logistic regression adjusted for confounding variables.
RESULTS:
Out of a total of 8022 older adults with a mean age of 70.6 years, the prevalence of a past medical history of cancer was 3.6 % (n = 288). Among these participants, 45.1 % had been diagnosed with cancer more than 10 years previously. A higher risk of incident frailty compared to controls [odds ratio (OR) 1.53 (95 % confidence interval (CI) 1.04-2.26, p = 0.03); adjusted model OR 1.74 (95 % CI 1.15-2.61, p = 0.008)] was found in the group with a recent cancer diagnosis. Also, an inverse association between a remote cancer diagnosis and worsening frailty was found [OR = 0.56 (95 % CI 0.39-0.8), p = 0.002; adjusted model OR 0.61 (95 % CI 0.38-0.99, p = 0.046)].
CONCLUSIONS:
Cancer is associated with a higher frailty index, with a potential relevant role of the time that has elapsed since the cancer diagnosis.
IMPLICATIONS FOR CANCER SURVIVORS:
Cancer survivors may be more likely to develop frailty or worsening of the health status at an older age. This relationship seems especially evident among individuals with a recent oncological diagnosis. Health professionals in charge of older adult care should be aware of this association in order to improve outcomes of older adults who survived cancer.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chronic disease; Disability; Frailty; Oncogeriatrics; Aged; Aging; Case-Control Studies; Cohort Studies; Female; Frail Elderly; Health Status; Humans; Male; Mexico; Neoplasms; Prevalence; Survivors; Oncology; Oncology (nursing)
Elenco autori:
M.U. Pérez-Zepeda, E. Cárdenas-Cárdenas, M. Cesari, A.P. Navarrete-Reyes, L.M. Gutiérrez-Robledo
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