HDL-cholesterol and physical performance: Results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study)
Articolo
Data di Pubblicazione:
2007
Citazione:
HDL-cholesterol and physical performance: Results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study) / F. Landi, A. Russo, M. Cesari, M. Pahor, R. Bernabei, G. Onder. - In: AGE AND AGEING. - ISSN 0002-0729. - 36:5(2007), pp. 514-520.
Abstract:
Background: High-density lipoprotein (HDL) cholesterol has been hypothesised to be a reliable marker of frailty and poor prognosis among the oldest elderly. We evaluate the relationship of HDL-cholesterol with measures of physical performance, muscle strength, and functional status in older persons aged 80years or older. Methods: Data are from baseline evaluation of the ageing and longevity study in the Sirente geographic area (ilSIRENTE study) (n = 364). Physical performance was assessed using the physical performance battery score [short physical performance battery (SPPB)], which is based on three-timed tests: 4-m walking-speed, balance, and chair-stand tests. Muscle strength was measured by hand-grip strength. Analyses of covariance were performed to evaluate the relationship of different HDL-cholesterol levels with physical function. Results: In the unadjusted analyses, physical function (as measured by the 4-m walking-speed, theSPPB score, the basic and instrumental activities of daily living scales scores), but not hand-grip strength, improved significantly as HDL-cholesterol tertiles increased. After adjustment for potential confounders, which included age, gender, living alone, alcohol abuse, physical activity, congestive heart failure, diabetes, cerebrovascular diseases, osteoarthritis, albumin, urea, C-reactive protein and LDL cholesterol, the association of HDL-cholesterol tertiles with the 4-m walking-speed and the SPPB score was still consistent. Conclusion: The present study suggests that among very old subjects living in the community the higher levels of HDL-cholesterol are associated with better functional performance.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Elderly; Frail; HDL-cholesterol; Physical performance; Aged; Aged, 80 and over; Aging; Cholesterol, HDL; Cohort Studies; Female; Hand Strength; Humans; Italy; Male; Muscle Strength; Postural Balance; Walking; Longevity; Physical Fitness; Aging
Elenco autori:
F. Landi, A. Russo, M. Cesari, M. Pahor, R. Bernabei, G. Onder
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