Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats
Articolo
Data di Pubblicazione:
2004
Citazione:
Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats / C.S. Carter, M. Cesari, W.T. Ambrosius, N. Hu, D. Diz, S. Oden, W.E. Sonntag, M. Pahor. - In: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. - ISSN 1079-5006. - 59:5(2004 May), pp. 416-423.
Abstract:
This study was designed to test the effects of angiotensin-converting enzyme (ACE) inhibition on body composition and physical performance in aged rats. Male Brown Norway x F344 rats were randomized to receive daily injections of enalapril (40 mg/kg or 80 mg/kg) or saline from 24 to 30 months of age. Body composition was determined using dual-energy X-ray absorptiometry (DXA), and physical performance was assessed using the grip strength and inclined plane procedures. Performance measures were assessed at baseline and monthly thereafter. DXA was performed at baseline, 3 months, and 6 months of follow-up. Compared with the enalapril groups, the saline group experienced a greater 6-month decline in the physical performance measures. Lean body mass declined in both groups; however, the enalapril groups also experienced a significant loss of fat mass. These results suggest that ACE inhibition may prevent age-related declines in physical performance, which may be mediated by a reduction in body fat mass.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Age Factors; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Composition; Enalapril; Male; Random Allocation; Rats; Rats, Inbred BN; Rats, Inbred F344; Physical Conditioning, Animal
Elenco autori:
C.S. Carter, M. Cesari, W.T. Ambrosius, N. Hu, D. Diz, S. Oden, W.E. Sonntag, M. Pahor
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