Major depression and bipolar disorders in CADASIL : a study using the DSM-IV semi-structured interview
Articolo
Data di Pubblicazione:
2011
Citazione:
Major depression and bipolar disorders in CADASIL : a study using the DSM-IV semi-structured interview / R. Valenti, F. Pescini, S. Antonini, G. Castellini, A. Poggesi, S. Bianchi, D. Inzitari, S. Pallanti, L. Pantoni. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - 124:6(2011 Dec), pp. 390-395.
Abstract:
OBJECTIVE:
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral microangiopathy characterized by migraine, cerebrovascular events, and cognitive impairment. Although recognized as a cardinal feature of the disease, psychiatric disturbances have rarely been the object of focused studies. We performed a structured evaluation of mood disorders in CADASIL.
MATERIALS AND METHODS:
Twenty-three patients with CADASIL (five men and 18 women) were assessed by psychiatrists using the Structured Clinical Interview for the DSM-IV, clinician version. For the quantitative assessment of current mood disorder symptoms, the Hamilton Rating Scale for Depression (HRSD) and the Young Mania Rating Scale (YMRS) were used.
RESULTS:
A lifetime depressive episode was recorded in 17/23 (73.9%) patients with CADASIL. Six (26.1%) patients with CADASIL reported a current depressive episode. A diagnosis of manic lifetime episode was made in 6 (26.1%) patients with CADASIL. The HRSD mean score in patients with current depression was 9.1 ± SD 8.1. The YMRS mean score was 14.2 ± SD 4.1 for manic CADASIL.
CONCLUSION:
This study confirms that mood disorders are frequent in CADASIL. The use of a structured psychiatric interview outlines a frequency of depression higher than that previously reported but also reveals a considerable frequency of bipolar disorders. If confirmed in larger series, these data suggest that a greater attention should be paid to the psychiatric aspects in CADASIL.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bipolar disorders; CADASIL; Depression; Diagnosis; DSM-IV; Mood disorders; Structured interview; Bipolar Disorder; CADASIL; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Interviews as Topic; Male; Middle Aged; Neuropsychological Tests; Neurology; Neurology (clinical)
Elenco autori:
R. Valenti, F. Pescini, S. Antonini, G. Castellini, A. Poggesi, S. Bianchi, D. Inzitari, S. Pallanti, L. Pantoni
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