Corpus callosum tissue loss and development of motor and global cognitive impairment : the LADIS study
Articolo
Data di Pubblicazione:
2011
Citazione:
Corpus callosum tissue loss and development of motor and global cognitive impairment : the LADIS study / K.S. Frederiksen, E. Garde, A. Skimminge, F. Barkhof, P. Scheltens, E.C.W. Van Straaten, F. Fazekas, H. Baezner, A. Verdelho, J.M. Ferro, T. Erkinjuntti, H. Jokinen, L. Wahlund, J.T. O'Brien, A.M. Basile, L. Pantoni, D. Inzitari, G. Waldemar. - In: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. - ISSN 1420-8008. - 32:4(2011), pp. 279-286.
Abstract:
Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cognitive impairment; Corpus callosum; Dementia; Magnetic resonance imaging; Motor function; Self-perceived memory impairment; Aged; Atrophy; Cognition Disorders; Corpus Callosum; Dementia; Disability Evaluation; Disease Progression; Female; Follow-Up Studies; Humans; Leukoaraiosis; Longitudinal Studies; Magnetic Resonance Imaging; Male; Movement Disorders; Neuropsychological Tests; Regression Analysis; Temporal Lobe; Geriatrics and Gerontology; Cognitive Neuroscience; Psychiatry and Mental Health
Elenco autori:
K.S. Frederiksen, E. Garde, A. Skimminge, F. Barkhof, P. Scheltens, E.C.W. Van Straaten, F. Fazekas, H. Baezner, A. Verdelho, J.M. Ferro, T. Erkinjuntti, H. Jokinen, L. Wahlund, J.T. O'Brien, A.M. Basile, L. Pantoni, D. Inzitari, G. Waldemar
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