Identification and Management of Statin-Associated Symptoms in Clinical Practice : Extension of a Clinician Survey to 12 Further Countries
Articolo
Data di Pubblicazione:
2017
Citazione:
Identification and Management of Statin-Associated Symptoms in Clinical Practice : Extension of a Clinician Survey to 12 Further Countries / R.S. Rosenson, S.R. Gandra, J. Mckendrick, R. Dent, H. Wieffer, L. Cheng, A.L. Catapano, O. Paul, G. Kees Hovingh, E.S. Stroes. - In: CARDIOVASCULAR DRUGS AND THERAPY. - ISSN 0920-3206. - 31:2(2017 Apr), pp. 187-195. [10.1007/s10557-017-6727-0]
Abstract:
Statins are the first-choice pharmacological treatment for patients with hypercholesterolemia and at risk for cardiovascular disease; however, a minority of patients experience statin-associated symptoms (SAS) and are considered to have reduced statin tolerance. The objective of this study was to establish how patients with SAS are identified and managed in clinical practice in Austria, Belgium, Colombia, Croatia, the Czech Republic, Denmark, Portugal, Switzerland, Russia, Saudi Arabia, Turkey, and the United Arab Emirates.
A cross-sectional survey was conducted (2015-2016) among clinicians (n = 60 per country; Croatia: n = 30) who are specialized/experienced in the treatment of hypercholesterolemia. Participants were asked about their experience of patients presenting with potential SAS and how such patients were identified and treated.
Muscle-related symptoms were the most common presentation of potential SAS (average: 51%; range across countries [RAC] 17-74%); other signs/symptoms included persistent elevation in transaminases. To establish whether symptoms are due to statins, clinicians required rechallenge after discontinuation of statin treatment (average: 77%; RAC 40-90%); other requirements included trying at least one alternative statin. Clinicians reported that half of high-risk patients with confirmed SAS receive a lower-dose statin (average: 53%; RAC 43-72%), and that most receive another non-statin lipid-lowering therapy with or without a concomitant statin (average: 65%; RAC 52-83%).
The specialists and GPs surveyed use stringent criteria to establish causality between statin use and signs or symptoms, and persevere with statin treatment where possible.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
clinical practice; hypercholesterolemia; reduced statin tolerance; statin-associated muscle symptoms; statin-associated symptoms; colombia; cross-sectional studies; dose-response relationship, drug; drug substitution; europe; health care surveys; humans; hydroxymethylglutaryl-coa reductase inhibitors; hypercholesterolemia; muscle, skeletal; muscular diseases; predictive value of tests; prevalence; risk assessment; risk factors; saudi arabia; united arab emirates; practice patterns, physicians'; pharmacology; cardiology and cardiovascular medicine; pharmacology (medical)
Elenco autori:
R.S. Rosenson, S.R. Gandra, J. Mckendrick, R. Dent, H. Wieffer, L. Cheng, A.L. Catapano, O. Paul, G. Kees Hovingh, E.S. Stroes
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