Development of an efficient and low-cost protocol for the manual PNA synthesis by Fmoc chemistry
Articolo
Data di Pubblicazione:
2010
Citazione:
Development of an efficient and low-cost protocol for the manual PNA synthesis by Fmoc chemistry / C. Avitabile, L. Moggio, L.D. D'Andrea, C. Pedone, A. Romanelli. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 51:29(2010), pp. 3716-3718.
Abstract:
An efficient and low-cost protocol for the manual synthesis of Peptide Nucleic Acids is reported here. The protocol relies on coupling reactions carried out with 2.5 equiv of PNA monomers activated with HOBT/HBTU, in the presence of pyridine/NMM. The protocol has been tested on four PNA oligomers with a length ranging from 9 to 12 bases and a purine content up to 67%.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Fmoc; Manual synthesis; Peptide nucleic acid; Pyridine
Elenco autori:
C. Avitabile, L. Moggio, L.D. D'Andrea, C. Pedone, A. Romanelli
Link alla scheda completa: