Data di Pubblicazione:
2012
Citazione:
β-Hairpin stabilization through an interstrand triazole bridge / V. Celentano, D. Diana, L. De Rosa, A. Romanelli, R. Fattorusso, L.D. D'Andrea. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 48:5(2012), pp. 762-764.
Abstract:
b-Hairpin peptides were conformationally stabilized through a
1,4 disubstituted 1,2,3-triazole interstrand linkage. A NMR
conformational analysis revealed that the b-hairpin content
depends on the number and position of substituent methylene
units of the 1,2,3-triazole ring. These results will allow the design
of metabolically stable peptidomimetic analogs of bioactive
b-hairpin peptides.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
peptide; beta hairpin; triazole bridge
Elenco autori:
V. Celentano, D. Diana, L. De Rosa, A. Romanelli, R. Fattorusso, L.D. D'Andrea
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