Data di Pubblicazione:
2018
Citazione:
Mineralocorticoid receptor antagonists for heart failure: a real-life observational study / B. Noemi, S. Gianfranco, P. Stefania, B. Alice, C. Ugo, P. Massimo, F. Veglia, E. Salvioni, L. Rocco, M. Metra, L. Giuseppe, C. Gaia, S. Angela B, C. Valentina, S. Domenico, B. Roberto, M. Guazzi, R. Rosa, G. Piero, M. Damiano, C. Michele, G. Parati, R. Federica, C. Mariantonietta, F. Maria, B. Maurizio, C. Vignati, O. Fabrizio, M. Alessandro, V. Giuseppe, D.L. Andrea, P. Claudio, S. Susanna, P. Giuseppe, R. Roberto, C. Mauro, A. Anna, P. Pietro, M. Mapelli, C. Cosimo, C. Francesco, B. Simone, B. Romualdo, L. Carlo, P. Perrone Filardi, E. Michele, P. Agostoni. - In: ESC HEART FAILURE. - ISSN 2055-5822. - (2018 Feb 04). [Epub ahead of print] [10.1002/ehf2.12244]
Abstract:
Aims
Mineralocorticoid receptor antagonists (MRAs) have been demonstrated to improve outcomes in reduced ejection fraction heart failure (HFrEF) patients. However, MRAs added to conventional treatment may lead to worsening of renal function and hyperkalaemia. We investigated, in a population-based analysis, the long-term effects of MRA treatment in HFrEF patients.
Methods and results
We analysed data of 6046 patients included in the Metabolic Exercise Cardiac Kidney Index score
dataset. Analysis was performed in patients treated (n= 3163) and not treated (n= 2883) with MRA. The study endpoint
was a composite of cardiovascular death, urgent heart transplantation, or left ventricular assist device implantation. Ten years’survival was analysed through Kaplan–Meier, compared by log-rank test and propensity score matching.
At 10 years’follow-up, the MRA-untreated group had a significantly lower number of events than the MRA-treated group (P<0.001). MRA-treated patients had more severe heart failure (higher New York Heart Association class and lower left ventricular ejection fraction, kidney function, and peak VO2). At a propensity-score-matching analysis performed on 1587 patients, MRA-treated and MRA-untreated patients showed similar study endpoint values.
Conclusions
In conclusion, MRA treatment does not affect the composite of cardiovascular death, urgent heart transplanta-
tion or left ventricular assist device implantation in a real-life setting. A meticulous patient follow-up, as performed in trials, is likely needed to match the positive MRA-related benefits observed in clinical trials.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
heart failure; hyperkalaemia; mineralocorticoid receptor antagonists; worsening renal function
Elenco autori:
B. Noemi, S. Gianfranco, P. Stefania, B. Alice, C. Ugo, P. Massimo, F. Veglia, E. Salvioni, L. Rocco, M. Metra, L. Giuseppe, C. Gaia, S. Angela B, C. Valentina, S. Domenico, B. Roberto, M. Guazzi, R. Rosa, G. Piero, M. Damiano, C. Michele, G. Parati, R. Federica, C. Mariantonietta, F. Maria, B. Maurizio, C. Vignati, O. Fabrizio, M. Alessandro, V. Giuseppe, D.L. Andrea, P. Claudio, S. Susanna, P. Giuseppe, R. Roberto, C. Mauro, A. Anna, P. Pietro, M. Mapelli, C. Cosimo, C. Francesco, B. Simone, B. Romualdo, L. Carlo, P. Perrone Filardi, E. Michele, P. Agostoni
Link alla scheda completa:
Link al Full Text: