The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training-II. The RehAtt Study : rationale, design and methodology
Articolo
Data di Pubblicazione:
2016
Citazione:
The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training-II. The RehAtt Study : rationale, design and methodology / E. Salvadori, A. Poggesi, R. Valenti, E. Della Rocca, S. Diciotti, M. Mascalchi, D. Inzitari, L. Pantoni. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 37:10(2016), pp. 1653-1662. [10.1007/s10072-016-2649-z]
Abstract:
Cerebral small vessel disease (SVD) may cause attentional and executive cognitive deficits. No drug is currently available to improve cognitive performance or to prevent dementia in SVD patients, and cognitive rehabilitation could be a promising approach. We aimed to investigate: (1) the effectiveness of the Attention Process Training-II program in the rehabilitation of patients with mild cognitive impairment (MCI) and SVD; (2) the impact of the induced cognitive improvement on functionality and quality of life; (3) the effect of training on brain activity at rest and the possibility of a training-induced plasticity effect. The RehAtt study is designed as a 3-year prospective, single-blinded, randomized clinical trial. Inclusion criteria were: (1) MCI defined according to Winblad et al. criteria; (2) evidence of impairment across attention neuropsychological tests; (3) evidence on MRI of moderate/severe white matter hyperintensities. All enrolled patients are evaluated at baseline, and after 6 and 12 months, according to an extensive clinical, functional, MRI and neuropsychological protocol. The baseline RehAtt cohort includes 44 patients (66 % males, mean ± SD age and years of education 75.3 ± 6.8 and 8.3 ± 4.3, respectively). After baseline assessment, patients have been randomly assigned to 'attention training' or 'standard care'. Treatments and follow-up visits at 6 months are completed, while follow-up visits at 12 months are ongoing. This study is the first attempt to reduce attention deficits in patients affected by MCI with SVD. The results of this pilot experience will represent an essential background for designing larger multicenter, prospective, double-blinded, randomized and controlled clinical trials.
TRIAL REGISTRATION:
NCT02033850 (ClinicalTrials.gov Identifier).
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Attention training; Cerebrovascular diseases; Cognitive rehabilitation; Mild cognitive impairment; Small vessel disease; Vascular dementia; Age Factors; Aged; Aged, 80 and over; Attention Deficit Disorder with Hyperactivity; Cerebral Small Vessel Diseases; Cognition Disorders; Cognitive Therapy; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Single-Blind Method; Treatment Outcome; 2708; Neurology (clinical); Psychiatry and Mental Health
Elenco autori:
E. Salvadori, A. Poggesi, R. Valenti, E. Della Rocca, S. Diciotti, M. Mascalchi, D. Inzitari, L. Pantoni
Link alla scheda completa: