Data di Pubblicazione:
2017
Citazione:
Thrombolysis in dementia patients with acute stroke : is it justified? / M. Paciaroni, L. Pantoni. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 38:1(2017), pp. 27-31. [10.1007/s10072-016-2725-4]
Abstract:
The administration of thrombolytic therapy in elderly patients with dementia and acute ischemic stroke may be controversial, because the reported risk of rt-PA associated intracerebral hemorrhage in these patients is higher compared with that of patients without dementia and because these patients are already disabled. Moreover, there are known risk factors for hemorrhagic transformation in patients with dementia: amyloid angiopathy, leukoaraiosis and the presence of microbleeds. In this review, we describe the impact of dementia on functional outcome following thrombolytic therapy for acute ischemic stroke and discuss some of the issues related to the use of this therapy in this specific patient' s population.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Amyloid angiopathy; Cerebral hemorrhage; Dementia; Outcome; rt-PA; Small vessel disease; Brain Ischemia; Cerebral Hemorrhage; Dementia; Fibrinolytic Agents; Humans; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; 2708; Neurology (clinical); Psychiatry and Mental Health
Elenco autori:
M. Paciaroni, L. Pantoni
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